Endocrine Abstracts

Background: This study prospectively assessed the sensitivity and positive predictive value (PPV) of ultrasound (US), ultrasound-guided fine needle aspiration with PTH measurement in the needle washout (US-FNA) and sestamibi scintigraphy (SS) for the localisation of parathyroid adenomas in patients with primary hyperparathyroidism (pHPT) and features of uniglandular disease.Methods: 51 consecutive patients with pHPT referred for first time surgery with a...

Introduction: Generously supported by IPSEN)-->Acquired isolated ACTH deficiency with normal secretion of the remaining pituitary hormones is a rare condition in the absence of exposure to exogenous glucocorticoids. The aetiology is assumed to be autoimmune in most adult cases with traumatic brain injury and radiation exposure being rare causes. Pituitary transcription factor mutations may be identified in congenital and childhood on...

A 58-year-old male patient presented with a 2 months history of bilateral frontotemporal headache, fatigue and impaired vision. Further exploration revealed short term memory losses, confusion, gait disturbances, decreased libido and erectile dysfunction. Radiological investigation showed a 4 cm pituitary mass with destruction of the upper clivus and left petrous apex associated with a 5 cm large suprasellar cyst bulging upward into the 3d ventricle with obstruction hydrocepha...

Background: Medical therapy with dopamine agonists (DA) is the primary treatment in most patients with prolactinomas. ‘Classical’ surgical indications are mainly intolerance of DA therapy or non-responders. Focusing on a possible shift of recent indications towards a surgical approach, we retrospectively analyzed the long-term results of surgical treatment and compared them to the medically treated female patients with prolactinomas.Patients an...

Background: In contrast to females with prolactinoma, male patients usually present with a history of long-standing hypogonadism and a macroadenoma on MRI-scan. Data is scarce about the effect of hypogonadism on bone health in these patients. We, therefore, investigated retrospectively the cohort of male patients with prolactinoma at our institution.Patients and methods: Between 1983 and 2007, the chards of 44 male patients with prolactinoma were reviewe...